Enrichment analysis of genes downregulated following Vitamin c treatment
Canned Analysis
FAIR Metrics
0 evaluations
General Information
AccessionDCA00056456
TitleEnrichment analysis of genes downregulated following Vitamin c treatment
DescriptionAn enrichment analysis was performed on the top 500 most downregulated genes identified by applying the Characteristic Direction method comparing gene expression between Vitamin c treated cells and untreated control cells in the Oct4-GiP mouse embryonic stem (ES) cells cell type.
Analysis URLhttp://amp.pharm.mssm.edu/Enrichr/enrich?dataset=1bv99
Upload DateSeptember 20, 2017
Uploadermaayanlab
Metadata
Analysis CuratorMicrotaskManic
CREEDS IDdrug:3506
Cell TypeOct4-GiP mouse embryonic stem (ES) cells
Drug NameVitamin c
DrugBank IDDB00126
Organismmouse
SMILES IDOC[C@@H]([C@H]1OC(=O)C(=C1O)O)O
Characteristic Direction parameters
Gene Setdownregulated
Gene Set Size500
Control SamplesGSM1128601, GSM1128602, GSM1128603
Perturbed SamplesGSM1128604, GSM1128605, GSM1128606
Tools used in the analysis
Keyword
Dataset Accession
Enrichr
Published May 2016
A comprehensive gene set enrichment analysis web server 2016 update
7759
65
Characteristic Direction
Published March 2014
A geometrical multivariate approach to identify differentially expressed genes
26829
Datasets used in the analysis
Keyword
Tool Name
GSE46319
Gene Expression Omnibus
Vitamin C induces Tet-dependent DNA demethylation in ES cells to promote a blastocyst-like methylome [Affymetrix]
7
FAIR Evaluation
Sorry, you must be signed in to evaluate this object.