Enrichment analysis of genes downregulated following Vitamin e treatment
Canned Analysis
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General Information
AccessionDCA00056472
TitleEnrichment analysis of genes downregulated following Vitamin e treatment
DescriptionAn enrichment analysis was performed on the top 500 most downregulated genes identified by applying the Characteristic Direction method comparing gene expression between Vitamin e treated cells and untreated control cells in the aorta cell type.
Analysis URLhttp://amp.pharm.mssm.edu/Enrichr/enrich?dataset=1buco
Upload DateSeptember 20, 2017
Uploadermaayanlab
Metadata
Analysis CuratorMicrotaskManic
CREEDS IDdrug:3515
Cell Typeaorta
Drug NameVitamin e
DrugBank IDDB00163
Organismmouse
PubChem CID14985
SMILES IDCC1=C(C(=C2CCC(OC2=C1C)(C)CCCC(C)CCCC(C)CCCC(C)C)C)O
Characteristic Direction parameters
Gene Setdownregulated
Gene Set Size500
Control SamplesGSM478610, GSM478611
Perturbed SamplesGSM1050380, GSM1050381
Tools used in the analysis
Keyword
Dataset Accession
Enrichr
Published May 2016
A comprehensive gene set enrichment analysis web server 2016 update
7759
65
Characteristic Direction
Published March 2014
A geometrical multivariate approach to identify differentially expressed genes
26829
Datasets used in the analysis
Keyword
Tool Name
GSE42813
Gene Expression Omnibus
Microarray gene expression profiling of aortic genes of APOE-deficient mice receiving atherosclerosis treatment with the antioxidant vitamin E
7
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