Enrichment analysis of genes downregulated in autism spectrum disorder
Canned Analysis
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General Information
AccessionDCA00059465
TitleEnrichment analysis of genes downregulated in autism spectrum disorder
DescriptionAn enrichment analysis was performed on the top 500 most downregulated genes identified by applying the Characteristic Direction method comparing gene expression between cells affected by autism spectrum disorder and healthy control cells in the lymphoblastoid cells cell type.
Analysis URLhttp://amp.pharm.mssm.edu/Enrichr/enrich?dataset=1btab
Upload DateSeptember 20, 2017
Uploadermaayanlab
Metadata
Analysis CuratorMicrotaskManic
CREEDS IDdz:1038
Cell Typelymphoblastoid cells
DO IDDOID:0060041
Disease Nameautism spectrum disorder
Organismhuman
Characteristic Direction parameters
Gene Setdownregulated
Gene Set Size500
Control SamplesGSM736476, GSM736477, GSM736478, GSM736479, GSM736480, GSM736481, GSM736482, GSM736483, GSM736484, GSM736485, GSM736486, GSM736487, GSM736488
Perturbed SamplesGSM736489, GSM736490
Tools used in the analysis
Keyword
Dataset Accession
Enrichr
Published May 2016
A comprehensive gene set enrichment analysis web server 2016 update
7759
65
Characteristic Direction
Published March 2014
A geometrical multivariate approach to identify differentially expressed genes
26829
Datasets used in the analysis
Keyword
Tool Name
GSE29691
Gene Expression Omnibus
Expression data from patients with global developmental delay and autistic features and normal controls
7
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