Enrichment analysis of genes downregulated in Werdnig-Hoffmann disease
Canned Analysis
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General Information
AccessionDCA00059579
TitleEnrichment analysis of genes downregulated in Werdnig-Hoffmann disease
DescriptionAn enrichment analysis was performed on the top 500 most downregulated genes identified by applying the Characteristic Direction method comparing gene expression between cells affected by Werdnig-Hoffmann disease and healthy control cells in the CNS - Spinal Cord (MMHCC) cell type.
Analysis URLhttp://amp.pharm.mssm.edu/Enrichr/enrich?dataset=1bu17
Upload DateSeptember 20, 2017
Uploadermaayanlab
Metadata
Analysis CuratorJoel.Dudley
CREEDS IDdz:126
Cell TypeCNS - Spinal Cord (MMHCC)
DO IDDOID:13137
Disease NameWerdnig-Hoffmann disease
Organismmouse
UMLS CUIC0043116
Characteristic Direction parameters
Gene Setdownregulated
Gene Set Size500
Control SamplesGSM67523, GSM67524, GSM67525
Perturbed SamplesGSM67526, GSM67529, GSM67530
Tools used in the analysis
Keyword
Dataset Accession
Enrichr
Published May 2016
A comprehensive gene set enrichment analysis web server 2016 update
7759
65
Characteristic Direction
Published March 2014
A geometrical multivariate approach to identify differentially expressed genes
26829
Datasets used in the analysis
Keyword
Tool Name
GSE3075
Gene Expression Omnibus
Neuromuscular degeneration mutant spinal cord response to neural stem cell transplantation
12
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