Enrichment analysis of genes downregulated in Down syndrome
Canned Analysis
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General Information
AccessionDCA00059953
TitleEnrichment analysis of genes downregulated in Down syndrome
DescriptionAn enrichment analysis was performed on the top 500 most downregulated genes identified by applying the Characteristic Direction method comparing gene expression between cells affected by Down syndrome and healthy control cells in the Fetus cell type.
Analysis URLhttp://amp.pharm.mssm.edu/Enrichr/enrich?dataset=1bu58
Upload DateSeptember 20, 2017
Uploadermaayanlab
Metadata
Analysis CuratorJoel.Dudley
CREEDS IDdz:310
Cell TypeFetus
DO IDDOID:14250
Disease NameDown syndrome
Organismhuman
UMLS CUIC0013080
Characteristic Direction parameters
Gene Setdownregulated
Gene Set Size500
Control SamplesGSM271303, GSM271312, GSM271479, GSM271480, GSM271481, GSM271482
Perturbed SamplesGSM271287, GSM271291, GSM271296, GSM271299
Tools used in the analysis
Keyword
Dataset Accession
Enrichr
Published May 2016
A comprehensive gene set enrichment analysis web server 2016 update
7759
65
Characteristic Direction
Published March 2014
A geometrical multivariate approach to identify differentially expressed genes
26829
Datasets used in the analysis
Keyword
Tool Name
GSE10758
Gene Expression Omnibus
Gene expression variation increase in trisomy 21 tissues
7
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