Enrichment analysis of genes downregulated in Niemann-Pick disease
Canned Analysis
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General Information
AccessionDCA00060269
TitleEnrichment analysis of genes downregulated in Niemann-Pick disease
DescriptionAn enrichment analysis was performed on the top 500 most downregulated genes identified by applying the Characteristic Direction method comparing gene expression between cells affected by Niemann-Pick disease and healthy control cells in the brain tissue cell type.
Analysis URLhttp://amp.pharm.mssm.edu/Enrichr/enrich?dataset=1btm0
Upload DateSeptember 20, 2017
Uploadermaayanlab
Metadata
Analysis Curatormmluxy
CREEDS IDdz:469
Cell Typebrain tissue
DO IDDOID:14504
Disease NameNiemann-Pick disease
Organismmouse
UMLS CUIC0220756
Characteristic Direction parameters
Gene Setdownregulated
Gene Set Size500
Control SamplesGSM973238, GSM973239, GSM973240, GSM973241, GSM973244, GSM973245, GSM973248, GSM973249, GSM973252, GSM973253, GSM973254, GSM973255, GSM973258, GSM973259, GSM973261, GSM973262
Perturbed SamplesGSM973242, GSM973243, GSM973246, GSM973247, GSM973250, GSM973251, GSM973256, GSM973257, GSM973260, GSM973263, GSM973264
Tools used in the analysis
Keyword
Dataset Accession
Enrichr
Published May 2016
A comprehensive gene set enrichment analysis web server 2016 update
7759
65
Characteristic Direction
Published March 2014
A geometrical multivariate approach to identify differentially expressed genes
26829
Datasets used in the analysis
Keyword
Tool Name
GSE39621
Gene Expression Omnibus
Niemann-Pick Type C disease spleen: time course
7
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