Enrichment analysis of genes downregulated in KMT2A MLL chromosomal translocation (tMLL) compared to partial tandem
Canned Analysis
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General Information
AccessionDCA00064509
TitleEnrichment analysis of genes downregulated in KMT2A MLL chromosomal translocation (tMLL) compared to partial tandem
DescriptionAn enrichment analysis was performed on the top 500 most downregulated genes identified by applying the Characteristic Direction method comparing gene expression between KMT2A MLL chromosomal translocation (tMLL) compared to partial tandem cells and control cells in the bone marrow mononuclear cells cell type.
Analysis URLhttp://amp.pharm.mssm.edu/Enrichr/enrich?dataset=1bzom
Upload DateSeptember 20, 2017
Uploadermaayanlab
Metadata
Analysis CuratorVICENTE
CREEDS IDgene:1506
Cell Typebone marrow mononuclear cells
Gene Symbol (human)KMT2A
Gene Symbol (mouse)Kmt2a
Organismhuman
Perturbation TypeMLL chromosomal translocation (tMLL) compared to partial tandem
Characteristic Direction parameters
Gene Setdownregulated
Gene Set Size500
Control SamplesGSM304968, GSM307951, GSM307952, GSM307953, GSM307957, GSM307958, GSM307959, GSM307960, GSM307961, GSM307966
Perturbed SamplesGSM366160, GSM366161, GSM366162, GSM366163, GSM366164, GSM366165, GSM366166, GSM366167, GSM366168, GSM366169, GSM366170, GSM366171, GSM366172, GSM366173, GSM366174
Tools used in the analysis
Keyword
Dataset Accession
Enrichr
Published May 2016
A comprehensive gene set enrichment analysis web server 2016 update
7759
65
Characteristic Direction
Published March 2014
A geometrical multivariate approach to identify differentially expressed genes
26829
Datasets used in the analysis
Keyword
Tool Name
GSE15013
Gene Expression Omnibus
Mixed lineage leukemia gene rearrangements in acute myeloid leukemia: bone marrow mononuclear cells
7
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