Enrichment analysis of genes downregulated in ITK KO
Canned Analysis
FAIR Metrics
0 evaluations
General Information
AccessionDCA00064597
TitleEnrichment analysis of genes downregulated in ITK KO
DescriptionAn enrichment analysis was performed on the top 500 most downregulated genes identified by applying the Characteristic Direction method comparing gene expression between ITK KO cells and control cells in the unstimulated CD3+ T-cells (pooled thymus and spleen) cell type.
Analysis URLhttp://amp.pharm.mssm.edu/Enrichr/enrich?dataset=1c0ox
Upload DateSeptember 20, 2017
Uploadermaayanlab
Metadata
Analysis Curatorgszeto
CREEDS IDgene:1554
Cell Typeunstimulated CD3+ T-cells (pooled thymus and spleen)
Gene Symbol (human)ITK
Gene Symbol (mouse)Itk
Organismmouse
Perturbation TypeKO
Characteristic Direction parameters
Gene Setdownregulated
Gene Set Size500
Control SamplesGSM313166, GSM313167, GSM313168
Perturbed SamplesGSM313169, GSM313170
Tools used in the analysis
Keyword
Dataset Accession
Enrichr
Published May 2016
A comprehensive gene set enrichment analysis web server 2016 update
7759
65
Characteristic Direction
Published March 2014
A geometrical multivariate approach to identify differentially expressed genes
26829
Datasets used in the analysis
Keyword
Tool Name
GSE12466
Gene Expression Omnibus
Transcriptional signatures of Itk-deficient CD3+, CD4+ and CD8+ T-cells
7
FAIR Evaluation
Sorry, you must be signed in to evaluate this object.