Enrichment analysis of genes downregulated in OTX2 silencing
Canned Analysis
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General Information
AccessionDCA00064685
TitleEnrichment analysis of genes downregulated in OTX2 silencing
DescriptionAn enrichment analysis was performed on the top 500 most downregulated genes identified by applying the Characteristic Direction method comparing gene expression between OTX2 silencing cells and control cells in the D425 medulloblastoma (MB) cells cell type.
Analysis URLhttp://amp.pharm.mssm.edu/Enrichr/enrich?dataset=1bzc6
Upload DateSeptember 20, 2017
Uploadermaayanlab
Metadata
Analysis Curatorcadimo
CREEDS IDgene:163
Cell TypeD425 medulloblastoma (MB) cells
Gene Symbol (human)OTX2
Gene Symbol (mouse)Otx2
Organismhuman
Perturbation Typesilencing
Characteristic Direction parameters
Gene Setdownregulated
Gene Set Size500
Control SamplesGSM565194, GSM565195, GSM565196, GSM565197, GSM565198, GSM565199
Perturbed SamplesGSM565176, GSM565177, GSM565178, GSM565179, GSM565180, GSM565181, GSM565182, GSM565183, GSM565184, GSM565185, GSM565186, GSM565187, GSM565188, GSM565189, GSM565190, GSM565191, GSM565192, GSM565193
Tools used in the analysis
Keyword
Dataset Accession
Enrichr
Published May 2016
A comprehensive gene set enrichment analysis web server 2016 update
7759
65
Characteristic Direction
Published March 2014
A geometrical multivariate approach to identify differentially expressed genes
26829
Datasets used in the analysis
Keyword
Tool Name
GSE22875
Gene Expression Omnibus
Transcription factor OTX2 oncogene silencing effect on D425 medulloblastoma cell line: time course
7
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