Enrichment analysis of genes downregulated in PIK3CA activemutant
Canned Analysis
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General Information
AccessionDCA00065401
TitleEnrichment analysis of genes downregulated in PIK3CA activemutant
DescriptionAn enrichment analysis was performed on the top 500 most downregulated genes identified by applying the Characteristic Direction method comparing gene expression between PIK3CA activemutant cells and control cells in the MCF10A cell type.
Analysis URLhttp://amp.pharm.mssm.edu/Enrichr/enrich?dataset=1c0ii
Upload DateSeptember 20, 2017
Uploadermaayanlab
Metadata
Analysis CuratorAndrew
CREEDS IDgene:2042
Cell TypeMCF10A
Gene Symbol (human)PIK3CA
Gene Symbol (mouse)Pik3ca
Organismhuman
Perturbation Typeactivemutant
Characteristic Direction parameters
Gene Setdownregulated
Gene Set Size500
Control SamplesGSM443978, GSM443979, GSM443980
Perturbed SamplesGSM443984, GSM443985, GSM443986
Tools used in the analysis
Keyword
Dataset Accession
Enrichr
Published May 2016
A comprehensive gene set enrichment analysis web server 2016 update
7759
65
Characteristic Direction
Published March 2014
A geometrical multivariate approach to identify differentially expressed genes
26829
Datasets used in the analysis
Keyword
Tool Name
GSE17785
Gene Expression Omnibus
Endogenous expression of an oncogenic PI3K mutation leads to activated PI3K pathway signaling and an invasive phenotype
7
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