Enrichment analysis of genes downregulated in MYRF KO
Canned Analysis
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General Information
AccessionDCA00065749
TitleEnrichment analysis of genes downregulated in MYRF KO
DescriptionAn enrichment analysis was performed on the top 500 most downregulated genes identified by applying the Characteristic Direction method comparing gene expression between MYRF KO cells and control cells in the cell: Cultured oligodendrocytes genotype: Myelin-gene Regulatory Factor conditional knockout (MRF fl/fl, Olig2 wt/cre) cell type.
Analysis URLhttp://amp.pharm.mssm.edu/Enrichr/enrich?dataset=1c08n
Upload DateSeptember 20, 2017
Uploadermaayanlab
Metadata
Analysis Curatorgszeto
CREEDS IDgene:2306
Cell Typecell: Cultured oligodendrocytes genotype: Myelin-gene Regulatory Factor conditional knockout (MRF fl/fl, Olig2 wt/cre)
Gene Symbol (human)MYRF
Gene Symbol (mouse)Myrf
Organismmouse
Perturbation TypeKO
Characteristic Direction parameters
Gene Setdownregulated
Gene Set Size500
Control SamplesGSM387042, GSM387043, GSM387044, GSM387045
Perturbed SamplesGSM387039, GSM387040, GSM387041
Tools used in the analysis
Keyword
Dataset Accession
Enrichr
Published May 2016
A comprehensive gene set enrichment analysis web server 2016 update
7759
65
Characteristic Direction
Published March 2014
A geometrical multivariate approach to identify differentially expressed genes
26829
Datasets used in the analysis
Keyword
Tool Name
GSE15303
Gene Expression Omnibus
Identification of Myelin-gene Regulatory Factor as a Critical Transcriptional Regulator Required for CNS Myelination
7
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