Enrichment analysis of genes upregulated in ZBTB7A KO
Canned Analysis
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General Information
AccessionDCA00065872
TitleEnrichment analysis of genes upregulated in ZBTB7A KO
DescriptionAn enrichment analysis was performed on the top 500 most upregulated genes identified by applying the Characteristic Direction method comparing gene expression between ZBTB7A KO cells and control cells in the strain/background: C57BL/6 genotype/variation: Zbtb7a Flox/Flox Mx1-Cre+ (LRF homozygous knockout) age: 4 weeks cell type: FACS-sorted LT-HSCs (LSK IL7Ra-Flt3-CD150+CD48-) time point: 9 days after 1st pIpC injection Treatment protocol LT-HSCs were FACS-sorted from three Lrf knockout (Zbtb7a Flox/Flox Mx1-Cre+) and two control (Zbtb7a Flox/+ Mx1-Cre+) mice, nine days after the first pIpC injection. pIpC (250μg) was injected twice to induce Cre recombinase. cell type.
Analysis URLhttp://amp.pharm.mssm.edu/Enrichr/enrich?dataset=1c02a
Upload DateSeptember 20, 2017
Uploadermaayanlab
Metadata
Analysis Curatorgszeto
CREEDS IDgene:2380
Cell Typestrain/background: C57BL/6 genotype/variation: Zbtb7a Flox/Flox Mx1-Cre+ (LRF homozygous knockout) age: 4 weeks cell type: FACS-sorted LT-HSCs (LSK IL7Ra-Flt3-CD150+CD48-) time point: 9 days after 1st pIpC injection Treatment protocol LT-HSCs were FACS-so
Gene Symbol (human)ZBTB7A
Gene Symbol (mouse)Zbtb7a
Organismmouse
Perturbation TypeKO
Characteristic Direction parameters
Gene Setupregulated
Gene Set Size500
Control SamplesGSM1025390, GSM1025391
Perturbed SamplesGSM1025392, GSM1025393, GSM1025394
Tools used in the analysis
Keyword
Dataset Accession
Enrichr
Published May 2016
A comprehensive gene set enrichment analysis web server 2016 update
7759
65
Characteristic Direction
Published March 2014
A geometrical multivariate approach to identify differentially expressed genes
26829
Datasets used in the analysis
Keyword
Tool Name
GSE41839
Gene Expression Omnibus
Expression data from control and LRF (leukemia/lymphoma related factor)-deficient mouse LT-HSCs
7
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