Enrichment analysis of genes upregulated in CTLA4 KO
Canned Analysis
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General Information
AccessionDCA00065902
TitleEnrichment analysis of genes upregulated in CTLA4 KO
DescriptionAn enrichment analysis was performed on the top 500 most upregulated genes identified by applying the Characteristic Direction method comparing gene expression between CTLA4 KO cells and control cells in the T cells from 5C.C7 RAG2-/- CD45.1 and 5C.C7 RAG2-/- CD45.1 CTLA-4-/- mice were activated by immunization with MCC peptide and LPS and after 4 days sorted for RNA extraction. cell type.
Analysis URLhttp://amp.pharm.mssm.edu/Enrichr/enrich?dataset=1byau
Upload DateSeptember 20, 2017
Uploadermaayanlab
Metadata
Analysis Curatorgszeto
CREEDS IDgene:2400
Cell TypeT cells from 5C.C7 RAG2-/- CD45.1 and 5C.C7 RAG2-/- CD45.1 CTLA-4-/- mice were activated by immunization with MCC peptide and LPS and after 4 days sorted for RNA extraction.
Gene Symbol (human)CTLA4
Gene Symbol (mouse)Ctla4
Organismmouse
Perturbation TypeKO
Characteristic Direction parameters
Gene Setupregulated
Gene Set Size500
Control SamplesGSM921632, GSM921633, GSM921634
Perturbed SamplesGSM921635, GSM921636, GSM921637
Tools used in the analysis
Keyword
Dataset Accession
Enrichr
Published May 2016
A comprehensive gene set enrichment analysis web server 2016 update
7759
65
Characteristic Direction
Published March 2014
A geometrical multivariate approach to identify differentially expressed genes
26829
Datasets used in the analysis
Keyword
Tool Name
GSE37563
Gene Expression Omnibus
In vivo gene expression data from wild type and CTLA-4 KO 5C.C7 T cells
7
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