Enrichment analysis of genes upregulated in PRMT5 KO
Canned Analysis
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General Information
AccessionDCA00065906
TitleEnrichment analysis of genes upregulated in PRMT5 KO
DescriptionAn enrichment analysis was performed on the top 500 most upregulated genes identified by applying the Characteristic Direction method comparing gene expression between PRMT5 KO cells and control cells in the Neural stem/ progenitor cells cell type.
Analysis URLhttp://amp.pharm.mssm.edu/Enrichr/enrich?dataset=1byb0
Upload DateSeptember 20, 2017
Uploadermaayanlab
Metadata
Analysis CuratorRuta
CREEDS IDgene:2403
Cell TypeNeural stem/ progenitor cells
Gene Symbol (human)PRMT5
Gene Symbol (mouse)Prmt5
Organismmouse
Perturbation TypeKO
Characteristic Direction parameters
Gene Setupregulated
Gene Set Size500
Control SamplesGSM1100469, GSM1100470, GSM1100471, GSM1100472
Perturbed SamplesGSM1100473, GSM1100474, GSM1100475, GSM1100476
Tools used in the analysis
Keyword
Dataset Accession
Enrichr
Published May 2016
A comprehensive gene set enrichment analysis web server 2016 update
7759
65
Characteristic Direction
Published March 2014
A geometrical multivariate approach to identify differentially expressed genes
26829
Datasets used in the analysis
Keyword
Tool Name
GSE45269
Gene Expression Omnibus
Regulation of constitutive and alternative splicing by PRMT5 reveals a role for Mdm4 pre-mRNA in sensing defects in the spliceosomal machinery (BeadCh...
7
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