Enrichment analysis of genes downregulated in NOTCH3 KO
Canned Analysis
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General Information
AccessionDCA00066299
TitleEnrichment analysis of genes downregulated in NOTCH3 KO
DescriptionAn enrichment analysis was performed on the top 500 most downregulated genes identified by applying the Characteristic Direction method comparing gene expression between NOTCH3 KO cells and control cells in the Cerebral microvascular fragments cell type.
Analysis URLhttp://amp.pharm.mssm.edu/Enrichr/enrich?dataset=1byy7
Upload DateSeptember 20, 2017
Uploadermaayanlab
Metadata
Analysis CuratorCarolet
CREEDS IDgene:2648
Cell TypeCerebral microvascular fragments
Gene Symbol (human)NOTCH3
Gene Symbol (mouse)Notch3
Organismmouse
Perturbation TypeKO
Characteristic Direction parameters
Gene Setdownregulated
Gene Set Size500
Control SamplesGSM1331539, GSM1331540, GSM1331541
Perturbed SamplesGSM1331545, GSM1331546, GSM1331547
Tools used in the analysis
Keyword
Dataset Accession
Enrichr
Published May 2016
A comprehensive gene set enrichment analysis web server 2016 update
7759
65
Characteristic Direction
Published March 2014
A geometrical multivariate approach to identify differentially expressed genes
26829
Datasets used in the analysis
Keyword
Tool Name
GSE55203
Gene Expression Omnibus
Gene expression changes in brain vascularture in Notch3 knockout mice
7
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