Enrichment analysis of genes downregulated in PPARA agonist activation
Canned Analysis
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General Information
AccessionDCA00067327
TitleEnrichment analysis of genes downregulated in PPARA agonist activation
DescriptionAn enrichment analysis was performed on the top 500 most downregulated genes identified by applying the Characteristic Direction method comparing gene expression between PPARA agonist activation cells and control cells in the Isolated hepatocytes cell type.
Analysis URLhttp://amp.pharm.mssm.edu/Enrichr/enrich?dataset=1bwe4
Upload DateSeptember 20, 2017
Uploadermaayanlab
Metadata
Analysis Curatordsurujon
CREEDS IDgene:501
Cell TypeIsolated hepatocytes
Gene Symbol (human)PPARA
Gene Symbol (mouse)Ppara
Organismhuman
Perturbation Typeagonist activation
Characteristic Direction parameters
Gene Setdownregulated
Gene Set Size500
Control SamplesGSM432140, GSM432142, GSM432144, GSM432146, GSM432148, GSM432150, GSM432152, GSM432154, GSM432156, GSM432158, GSM432160, GSM432162
Perturbed SamplesGSM432139, GSM432141, GSM432143, GSM432145, GSM432147, GSM432149, GSM432151, GSM432153, GSM432155, GSM432157, GSM432159, GSM432161
Tools used in the analysis
Keyword
Dataset Accession
Enrichr
Published May 2016
A comprehensive gene set enrichment analysis web server 2016 update
7759
65
Characteristic Direction
Published March 2014
A geometrical multivariate approach to identify differentially expressed genes
26829
Datasets used in the analysis
Keyword
Tool Name
GSE17251
Gene Expression Omnibus
Comparative analysis of gene regulation by the transcription factor PPAR_human
7
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