Gene expression profile of right ventricles from adult wild type and Ezh2-deficient hearts
Transcriptomics Dataset
FAIR Metrics
0 evaluations
General Information
| Accession | GSE34274 |
| Title | Gene expression profile of right ventricles from adult wild type and Ezh2-deficient hearts |
| Description | Adult-onset diseases can be associated with in utero events, but mechanisms for this remain unknown. The polycomb histone methyltransferase, Ezh2, stabilizes transcription by depositing repressive marks during development that persist into adulthood, but its function in postnatal organ homeostasis is unknown. We show that Ezh2 stabilizes cardiac gene expression and prevents cardiac pathology by repressing the homeodomain transcription factor Six1, which functions in cardiac progenitors but is stably silenced upon cardiac differentiation. Ezh2 deletion in cardiac progenitors caused postnatal myocardial pathology and destabilized cardiac gene expression with activation of Six1-dependent skeletal muscle genes. Six1 induced cardiomyocyte hypertrophy and skeletal muscle gene expression. Furthermore, genetically reducing Six1 levels rescued the pathology of Ezh2-deficient hearts. Thus, Ezh2-mediated repression of Six1 in differentiating cardiac progenitors is essential for stable postnatal heart gene expression and homeostasis. Our results suggest that epigenetic dysregulation in embryonic progenitor cells predisposes to adult disease and dysregulated stress responses. |
| Landing Page | https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE34274 |
| Repository | Gene Expression Omnibus |
Related Datasets
GSE31223
Gene expression of polyoma middle T antigen induced mammary tumors [RNA_Seq : MOLF x PyMT]
1
GSE35350
Combined miRNA and mRNA Sequencing Identifies Protective Transcriptional Signature of Enhanced PI3Kalpha Signaling in Cardiac Hypertrophy
1
GSE35464
Genome-wide analysis of histone methylation reveals chromatin state-based regulation of host cellular gene expression induced by hepatitis B viruses (...
1
GSE36290
High-throughput sequencing of sequentially reprogrammed iPS cells reveals key epigenetic modifications correlated with reduced pluripotency of iPS cel...
1
GSE69726
Myocardin-related transcription factors are required for cardiac development and function
1
GSE79700
ISL1 and JMJD3 synergistically control cardiac differentiation of embryonic stem cells (RNA-Seq)
1
7
GSE30076
Polycomb histone methyltransferase Ezh2-deficient hearts: right ventricle and interventricular septum
7
Tools
used to analyze the dataset
Canned Analyses
generated with the dataset
FAIR Evaluation
Sorry, you must be signed in to evaluate this object.
