Mechanistic and structural insight into the functional dichotomy between interleukin-2 and interleukin-15
Transcriptomics Dataset
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| Accession | GSE40350 |
| Title | Mechanistic and structural insight into the functional dichotomy between interleukin-2 and interleukin-15 |
| Description | Interleukin-15 (IL-15) and IL-2 possess distinct immunological functions despite both signaling through IL-2R and the common cytokine receptor -chain, c, We find that in the IL-15/IL-15R/IL-2R/c quaternary complex structure, IL-15 heterodimerizes IL-2R and c identically to the IL-2/IL-2R/IL-2R/c complex, despite differing receptor-binding chemistries. IL-15R dramatically increases the affinity of IL-15 for IL-2R, and this allostery is required for IL-15 trans-signaling versus IL-2 cis-signaling. Consistent with the identical IL-2R/c dimer geometry, IL-2 and IL-15 exhibited similar signaling properties in lymphocytes, with any differences resulting from disparate receptor affinities. Thus, IL-15 and IL-2 induce similar signals, and the cytokine-specificity of IL-2R versus IL-15R determines cellular responsiveness. These results provide important new insights for specific development of IL-15- versus IL-2-based immunotherapeutics. |
| Landing Page | https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE40350 |
| Repository | Gene Expression Omnibus |
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