Identification of Novel Post-Transcriptional Features in Olfactory Receptor Family mRNAs
Transcriptomics Dataset
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General Information
| Accession | GSE57567 |
| Title | Identification of Novel Post-Transcriptional Features in Olfactory Receptor Family mRNAs |
| Description | Olfactory receptor (Olfr) genes comprise the largest gene family in mice. Despite their importance, most Olfr mRNAs are uncharacterized. Using RNA-seq analysis, we annotated the repertoire of mouse Olfr mRNAs expressed in the olfactory epithelium and found that they have several atypical features suggesting how post-transcriptional regulation impacts their expression. First, many Olfr mRNAs are intronless and those with introns typically have a single intron at the 5 end. Second, Olfr mRNAs, as a group, have dramatically higher average AU content and lower predicted secondary structure than do control mRNAs. Third, Olfr mRNAs have a higher density of AU-rich elements (AREs) than control mRNAs. Fourth, Olfr mRNAs have much shorter 3 UTR regions and fewer predicted binding sites for neurally expressed miRNAs than control mRNAs. Fifth, Olfr mRNAs have a significantly greater number of upstream open reading frames (uORFs) in their 5 UTR than control mRNAs. All of these novel properties correlated with higher Olfr expression. Finally, we identified striking differences in the mRNAs from the two classes of Olfr genes, a finding consistent with their independent evolutionary origin. Our study suggests that the Olfr gene family has encountered unusual selective forces that have driven these unique post-transcriptional regulatory features. |
| Landing Page | https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE57567 |
| Repository | Gene Expression Omnibus |
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