Rebalancing gene haploinsufficiency in vivo by targeting chromatin
Transcriptomics Dataset
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General Information
AccessionGSE79941
TitleRebalancing gene haploinsufficiency in vivo by targeting chromatin
DescriptionHere we show that the T-box transcription factor encoded by Tbx1 positively regulates monomethylation of histone 3 lysine 4 (H3K4me1) at a significant number of regions that it occupies throughout the genome, often located at the 3' end of target genes. Treatment of cells with Tranylcypromine (TCP), an inhibitor of histone demethylases, rescues the expression of approx. one third of the genes dysregulated by Tbx1 suppression and it rebalances H3K4me1 levels at many Tbx1 occupied sites. In addition, TCP treatment of mouse models of the 22q11.2DS ameliorates substantially the cardiovascular phenotype.
Landing Pagehttps://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE79941
RepositoryGene Expression Omnibus
Tools used to analyze the dataset
Dataset Accession
Clustergrammer
Published October 2017
Web-based tool for visualizing and analyzing high-dimensional data as interactive and shareable heatmaps
4645
ARCHS4
Published September 2017
ARCHS4 provides access to gene counts from HiSeq 2000 and HiSeq 2500 platforms for human and mouse experiments from GEO ...
4645
Canned Analyses generated with the dataset
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Tool Name
Interactive heatmap visualization of RNA-seq dataset GSE79941
ARCHS4, Clustergrammer
Highly interactive web-based heatmap visualization of the top 500 most variable genes in t...
Interactive heatmap visualization of RNA-seq dataset GSE79941
ARCHS4, Clustergrammer
Highly interactive web-based heatmap visualization of the top 500 most variable genes in t...
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