RNA-Seq data of CD4+ T cells from mice with Type-A vs Type-B EAE
Transcriptomics Dataset
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General Information
AccessionGSE85946
TitleRNA-Seq data of CD4+ T cells from mice with Type-A vs Type-B EAE
DescriptionPurpose: To compare gene expression of CD4+ T cells between Type-A and Type-B EAE Method: CD4+ T cells were FACS sorted from spleens 9-day post immunization. Results: We found that Type-B EAE (NLRP3 inflammasome-dependent and IFNb treatment-resistant EAE) express high levels of CXCR2 and other chemokine receptors, which can be targeted to treat the Type-A EAE subtypes, instead of treating with IFNb. Conclusions: Altering intensity of immunization significantly impacts on gene expression patterns in T cells.
Landing Pagehttps://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE85946
RepositoryGene Expression Omnibus
Tools used to analyze the dataset
Dataset Accession
ARCHS4
Published September 2017
ARCHS4 provides access to gene counts from HiSeq 2000 and HiSeq 2500 platforms for human and mouse experiments from GEO ...
4645
Clustergrammer
Published October 2017
Web-based tool for visualizing and analyzing high-dimensional data as interactive and shareable heatmaps
4645
Canned Analyses generated with the dataset
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Tool Name
Interactive heatmap visualization of RNA-seq dataset GSE85946
ARCHS4, Clustergrammer
Highly interactive web-based heatmap visualization of the top 500 most variable genes in t...
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