Transcriptomes of mouse N-Myc drived B-Acute-Lymphoblastic-Leukemia (B-ALL) leukemia cells treated with fasting
Transcriptomics Dataset
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General Information
AccessionGSE89622
TitleTranscriptomes of mouse N-Myc drived B-Acute-Lymphoblastic-Leukemia (B-ALL) leukemia cells treated with fasting
DescriptionWe reported that fasting completely inhibits the development of Acute Lymphoblastic Leukemia (ALL) in mouse models, by inducing a rapid differentiation and clearance of ALL cells. To determine the underlying mechanisms, we transplanted N-Myc expressed lineage negative (Lin-) fetal live cells with a GFP reporter into mice to initiate B-ALL development. At the middle stage of B-ALL development when GFP+%% in PB reached about 60%%, the B-ALL mice were fasted 1-day or 2-days. GFP+B220+ B-ALL cells from 1-day, 2-day fasted mice and control mice were collected by flow cytometry for RNA-seq analysis.
Landing Pagehttps://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE89622
RepositoryGene Expression Omnibus
Tools used to analyze the dataset
Dataset Accession
ARCHS4
Published September 2017
ARCHS4 provides access to gene counts from HiSeq 2000 and HiSeq 2500 platforms for human and mouse experiments from GEO ...
4645
Clustergrammer
Published October 2017
Web-based tool for visualizing and analyzing high-dimensional data as interactive and shareable heatmaps
4645
Canned Analyses generated with the dataset
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Tool Name
Interactive heatmap visualization of RNA-seq dataset GSE89622
ARCHS4, Clustergrammer
Highly interactive web-based heatmap visualization of the top 500 most variable genes in t...
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