ART
Computational Tool
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General Information
DescriptionA next-generation sequencing read simulator
Homepagehttp://www.niehs.nih.gov/research/resources/software/art
Publications
ART: a next-generation sequencing read simulator
Weichun Huang; Leping Li; Jason R. Myers; Gabor T. Marth
Summary: ART is a set of simulation tools that generate synthetic next-generation sequencing reads. This functionality is essential for testing and benchmarking tools for next-generation sequencing data analysis including read alignment, de novo assembly and genetic variation discovery. ART generates simulated sequencing reads by emulating the sequencing process with built-in, technology-specific read error models and base quality value profiles parameterized empirically in large sequencing datasets. We currently support all three major commercial next-generation sequencing platforms: Roche's 454, Illumina's Solexa and Applied Biosystems' SOLiD. ART also allows the flexibility to use customized read error model parameters and quality profiles.
Availability: Both source and binary software packages are available at http://www.niehs.nih.gov/research/resources/software/art
Contact: weichun.huang@nih.gov; gabor.marth@bc.edu
Supplementary information: Supplementary data are available at Bioinformatics online.
DOI: https://doi.org/10.1093/bioinformatics/btr708
Metrics:
158
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