General Information
| Description | Cracking the LAnguage of Regulatory Elements |
| Homepage | http://clare.dcode.org/ |
Publications
CLARE: Cracking the LAnguage of Regulatory Elements
Summary:
CLARE is a computational method designed to reveal sequence encryption of tissue-specific regulatory elements. Starting with a set of regulatory elements known to be active in a particular tissue/process, it learns the sequence code of the input set and builds a predictive model from features specific to those elements. The resulting model can then be applied to user-supplied genomic regions to identify novel candidate regulatory elements. CLARE's model also provides a detailed analysis of transcription factors that most likely bind to the elements, making it an invaluable tool for understanding mechanisms of tissue-specific gene regulation.
Availability:
CLARE is freely accessible at http://clare.dcode.org/.
Contact:
taherl@ncbi.nlm.nih.gov; ovcharen@nih.gov
Supplementary information:
Supplementary data are available at Bioinformatics online.
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