Cas-Designer
Computational Tool
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General Information
DescriptionA web-based tool for choice of CRISPR-Cas9 target sites
Homepagehttp://rgenome.net/cas-designer/
Publications
Cas-Designer: a web-based tool for choice of CRISPR-Cas9 target sites
Jeongbin Park; Sangsu Bae; Jin-Soo Kim
Summary: We present Cas-Designer, a user-friendly program to aid researchers in choosing appropriate target sites in a gene of interest for type II CRISPR/Cas-derived RNA-guided endonucleases, which are now widely used for biomedical research and biotechnology. Cas-Designer rapidly provides the list of all possible guide RNA sequences in a given input DNA sequence and their potential off-target sites including bulge-type sites in a genome of choice. In addition, the program assigns an out-of-frame score to each target site to help users choose appropriate sites for gene knockout. Cas-Designer shows the results in an interactive table and provides user-friendly filter functions.
Availability and implementation: Free access at http://rgenome.net/cas-designer/.
Contact: sangsubae@hanyang.ac.kr or jskim01@snu.ac.kr
Supplementary information: Supplementary data are available at Bioinformatics online.
DOI: https://doi.org/10.1093/bioinformatics/btv537
Metrics:
9
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