General Information
| Description | An R package for flexible identification of differentially expressed subpathways using RNA-seq experiments |
| Homepage | http://bioconductor.org/packages/DEsubs/ |
Publications
DEsubs: an R package for flexible identification of differentially expressed subpathways using RNA-seq experiments
Summary:
DEsubs is a network-based systems biology R package that extracts disease-perturbed subpathways within a pathway network as recorded by RNA-seq experiments. It contains an extensive and customized framework with a broad range of operation modes at all stages of the subpathway analysis, enabling so a case-specific approach. The operation modes include pathway network construction and processing, subpathway extraction, visualization and enrichment analysis with regard to various biological and pharmacological features. Its capabilities render DEsubs a tool-guide for both the modeler and experimentalist for the identification of more robust systems-level drug targets and biomarkers for complex diseases.
Availability and Implementation:
DEsubs is implemented as an R package following Bioconductor guidelines: http://bioconductor.org/packages/DEsubs/.
Contact:
tassos.bezerianos@nus.edu.sg
Supplementary information:
Supplementary data are available at Bioinformatics online.
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