General Information
| Description | A method to identify recurrent DNA copy number aberrations in tumors |
| Homepage | http://www.bios.unc.edu/research/genomic_software/DiNAMIC |
Publications
DiNAMIC: a method to identify recurrent DNA copy number aberrations in tumors
Motivation:
DNA copy number gains and losses are commonly found in tumor tissue, and some of these aberrations play a role in tumor genesis and development. Although high resolution DNA copy number data can be obtained using array-based techniques, no single method is widely used to distinguish between recurrent and sporadic copy number aberrations.
Results:
Here we introduce Discovering Copy Number Aberrations Manifested In Cancer (DiNAMIC), a novel method for assessing the statistical significance of recurrent copy number aberrations. In contrast to competing procedures, the testing procedure underlying DiNAMIC is carefully motivated, and employs a novel cyclic permutation scheme. Extensive simulation studies show that DiNAMIC controls false positive discoveries in a variety of realistic scenarios. We use DiNAMIC to analyze two publicly available tumor datasets, and our results show that DiNAMIC detects multiple loci that have biological relevance.
Availability:
Source code implemented in R, as well as text files containing examples and sample datasets are available at http://www.bios.unc.edu/research/genomic_software/DiNAMIC.
Contact:
vwalter@email.unc.edu; fwright@bios.unc.edu
Supplementary information:
Supplementary data are available at Bioinformatics online.
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