General Information
| Description | A rational pipeline for epitope immunogenicity characterization |
| Homepage | http://saphire.usask.ca/saphire/epic |
Publications
EpIC: a rational pipeline for epitope immunogenicity characterization
Summary:
Efforts to develop peptide-based vaccines, in particular those requiring site-specific targeting of self-proteins, rely on the ability to optimize the immunogenicity of the peptide epitopes. Currently, screening of candidate vaccines is typically performed through low-throughput, high-cost animal trials. To improve on this we present the program EpIC, which enables high-throughput prediction of peptide immunogenicity based on the endogenous occurrence of B-cell epitopes within native protein sequences. This information informs rational selection of immunogenicity-optimized epitopes for peptide vaccines.
Availability and implementation:
EpIC is available as a web server at http://saphire.usask.ca/saphire/epic.
Contact:
kdm449@mail.usask.ca
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