General Information
| Description | A practical method for the discovery of genomic rearrangements at breakpoint resolution |
| Homepage | http://factera.stanford.edu |
Publications
FACTERA: a practical method for the discovery of genomic rearrangements at breakpoint resolution
Summary:
For practical and robust de novo identification of genomic fusions and breakpoints from targeted paired-end DNA sequencing data, we developed Fusion And Chromosomal Translocation Enumeration and Recovery Algorithm (FACTERA). Our method has minimal external dependencies, works directly on a preexisting Binary Alignment/Map file and produces easily interpretable output. We demonstrate FACTERA’s ability to rapidly identify breakpoint-resolution fusion events with high sensitivity and specificity in patients with non-small cell lung cancer, including novel rearrangements. We anticipate that FACTERA will be broadly applicable to the discovery and analysis of clinically relevant fusions from both targeted and genome-wide sequencing datasets.
Availability and implementation:
http://factera.stanford.edu.
Contact:
arasha@stanford.edu or diehn@stanford.edu
Supplementary information:
Supplementary data are available at Bioinformatics online.
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