General Information
| Description | Multi-purpose statistical analysis of genome-wide chromatin 3D organization |
| Homepage | http://hyperbrowser.uio.no/3d |
Publications
HiBrowse: multi-purpose statistical analysis of genome-wide chromatin 3D organization
Summary:
Recently developed methods that couple next-generation sequencing with chromosome conformation capture-based techniques, such as Hi-C and ChIA-PET, allow for characterization of genome-wide chromatin 3D structure. Understanding the organization of chromatin in three dimensions is a crucial next step in the unraveling of global gene regulation, and methods for analyzing such data are needed. We have developed HiBrowse, a user-friendly web-tool consisting of a range of hypothesis-based and descriptive statistics, using realistic assumptions in null-models.
Availability and implementation:
HiBrowse is supported by all major browsers, and is freely available at http://hyperbrowser.uio.no/3d. Software is implemented in Python, and source code is available for download by following instructions on the main site.
Contact:
jonaspau@ifi.uio.no
Supplementary Information:
Supplementary data are available at Bioinformatics online.
Related Tools
Hi-Corrector
Published November 2014
A fast, scalable and memory-efficient package for normalizing large-scale Hi-C data
CAME
Published December 2016
Identification of chromatin accessibility from nucleosome occupancy and methylome sequencing
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