General Information
| Description | Sensitive detection of somatic mutations from deep amplicon sequencing |
| Homepage | http://sourceforge.net/projects/mutascope/ |
Publications
Mutascope: sensitive detection of somatic mutations from deep amplicon sequencing
Summary:
We present Mutascope, a sequencing analysis pipeline specifically developed for the identification of somatic variants present at low-allelic fraction from high-throughput sequencing of amplicons from matched tumor-normal specimen. Using datasets reproducing tumor genetic heterogeneity, we demonstrate that Mutascope has a higher sensitivity and generates fewer false-positive calls than tools designed for shotgun sequencing or diploid genomes.
Availability:
Freely available on the web at http://sourceforge.net/projects/mutascope/.
Contact:
oharismendy@ucsd.edu
Supplementary information:
Supplementary data are available at Bioinformatics online.
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