General Information
| Description | A statistical approach for the identification of somatic copy number alterations from next-generation sequencing of cancer genomes |
| Homepage | https://sites.google.com/site/oncosnpseq/ |
Publications
OncoSNP-SEQ: a statistical approach for the identification of somatic copy number alterations from next-generation sequencing of cancer genomes
Summary:
Recent major cancer genome sequencing studies have used whole-genome sequencing to detect various types of genomic variation. However, a number of these studies have continued to rely on SNP array information to provide additional results for copy number and loss-of-heterozygosity estimation and assessing tumour purity. OncoSNP-SEQ is a statistical model-based approach for inferring copy number profiles directly from high-coverage whole genome sequencing data that is able to account for unknown tumour purity and ploidy.
Availability:
MATLAB code is available at the following URL: https://sites.google.com/site/oncosnpseq/.
Contact
: c.yau@imperial.ac.uk
Supplementary information:
Supplementary data are available at Bioinformatics online.
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