General Information
| Description | A flexible tool for identifying pleiotropic pathways using genome-wide association study summaries |
| Homepage | http://sourceforge.net/projects/papav1/files/ |
Publications
PAPA: a flexible tool for identifying pleiotropic pathways using genome-wide association study summaries
Summary
: Pleiotropy is common in the genetic architectures of complex diseases. To the best of our knowledge, no analysis tool has been developed for identifying pleiotropic pathways using multiple genome-wide association study (GWAS) summaries by now. Here, we present PAPA, a flexible tool for pleiotropic pathway analysis utilizing GWAS summary results. The performance of PAPA was validated using publicly available GWAS summaries of body mass index and waist-hip ratio of the GIANT datasets. PAPA identified a set of pleiotropic pathways, which have been demonstrated to be involved in the development of obesity.
Availability and implementation
PAPA program, document and illustrative example are available at http://sourceforge.net/projects/papav1/files/.
Contact
fzhxjtu@mail.xjtu.edu.cn
Supplementary information:
Supplementary data are available at Bioinformatics online.
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