PUGSVM
Computational Tool
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General Information
DescriptionA caBIG analytical tool for multiclass gene selection and predictive classification
Homepagehttp://www.cbil.ece.vt.edu/caBIG-PUGSVM.htm
Publications
PUGSVM: a caBIG analytical tool for multiclass gene selection and predictive classification
Guoqiang Yu; Huai Li; Sook Ha; Ie−Ming Shih; Robert Clarke; Eric P. Hoffman; Subha Madhavan; Jianhua Xuan; Yue Wang
Summary: Phenotypic Up-regulated Gene Support Vector Machine (PUGSVM) is a cancer Biomedical Informatics Grid (caBIG™) analytical tool for multiclass gene selection and classification. PUGSVM addresses the problem of imbalanced class separability, small sample size and high gene space dimensionality, where multiclass gene markers are defined by the union of one-versus-everyone phenotypic upregulated genes, and used by a well-matched one-versus-rest support vector machine. PUGSVM provides a simple yet more accurate strategy to identify statistically reproducible mechanistic marker genes for characterization of heterogeneous diseases.
Availability: http://www.cbil.ece.vt.edu/caBIG-PUGSVM.htm.
Contact: yuewang@vt.edu
Supplementary information: Supplementary data are available at Bioinformatics online.
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