General Information
| Description | Estimating purity of human tumor samples using next-generation sequencing data |
| Homepage | http://odin.mdacc.tmc.edu/~xsu1/PurityEst.html |
Publications
PurityEst: estimating purity of human tumor samples using next-generation sequencing data
Summary:
We developed a novel algorithm, PurityEst, to infer the tumor purity level from the allelic differential representation of heterozygous loci with somatic mutations in a human tumor sample with a matched normal tissue using next-generation sequencing data. We applied our tool to a whole cancer genome sequencing datasets and demonstrated the accuracy of PurityEst compared with DNA copy number-based estimation.
Availability:
PurityEst has been implemented in PERL and is available at http://odin.mdacc.tmc.edu/~xsu1/PurityEst.html
Contact:
xsu1@mdanderson.org
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