General Information
| Description | Simulate multiple disease sites in large pedigrees with given disease status for diseases with low prevalence |
| Homepage | http://seqsimla.sourceforge.net |
Publications
SeqSIMLA2_exact: simulate multiple disease sites in large pedigrees with given disease status for diseases with low prevalence
Summary:
It is difficult for current simulation tools to simulate sequence data in a pre-specified pedigree structure and pre-specified affection status. Previously, we developed a flexible tool, SeqSIMLA2, for simulating sequence data in either unrelated case-control or family samples with different disease and quantitative trait models. Here we extended the tool to efficiently simulate sequences with multiple disease sites in large pedigrees with a given disease status for each pedigree member, assuming that the disease prevalence is low.
Availability and implementation:
SeqSIMLA2_exact is implemented with C++ and is available at http://seqsimla.sourceforge.net .
Contact:
rchung@nhri.org.tw
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