General Information
| Description | A GUI for interactive constraint network analysis and protein engineering for improving thermostability |
| Homepage | http://flexweb.asu.edu |
Publications
VisualCNA: a GUI for interactive constraint network analysis and protein engineering for improving thermostability
Summary:
Constraint network analysis (CNA) is a graph theory-based rigidity analysis approach for linking a biomolecule’s structure, flexibility, (thermo)stability and function. Results from CNA are highly information-rich and require intuitive, synchronized and interactive visualization for a comprehensive analysis. We developed VisualCNA, an easy-to-use PyMOL plug-in that allows setup of CNA runs and analysis of CNA results linking plots with molecular graphics representations. From a practical viewpoint, the most striking feature of VisualCNA is that it facilitates interactive protein engineering aimed at improving thermostability.
Availability and Implementation:
VisualCNA and its dependencies (CNA and FIRST software) are available free of charge under GPL and academic licenses, respectively. VisualCNA and CNA are available at http://cpclab.uni-duesseldorf.de/software; FIRST is available at http://flexweb.asu.edu.
Contact:
gohlke@uni-duesseldorf.de
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