XDIA
Computational Tool
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General Information
DescriptionImproving on the label-free data-independent analysis
Homepagehttp://fields.scripps.edu/XDIA
Publications
XDIA: improving on the label-free data-independent analysis
Paulo C. Carvalho; Xuemei Han; Tao Xu; Daniel Cociorva; Maria da Gloria Carvalho; Valmir C. Barbosa; John R. Yates, III
Summary: XDIA is a computational strategy for analyzing multiplexed spectra acquired using electron transfer dissociation and collision-activated dissociation; it significantly increases identified spectra (∼250%) and unique peptides (∼30%) when compared with the data-dependent ETCaD analysis on middle-down, single-phase shotgun proteomic analysis. Increasing identified spectra and peptides improves quantitation statistics confidence and protein coverage, respectively.
Availability: The software and data produced in this work are freely available for academic use at http://fields.scripps.edu/XDIA
Contact: paulo@pcarvalho.com
Supplementary information: Supplementary data are available at Bioinformatics online.
DOI: https://doi.org/10.1093/bioinformatics/btq031
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