genBlastG
Computational Tool
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General Information
DescriptionUsing BLAST searches to build homologous gene models
Homepagehttp://genome.sfu.ca/genblast/download.html
Publications
genBlastG: using BLAST searches to build homologous gene models
Rong She; Jeffrey Shih-Chieh Chu; Bora Uyar; Jun Wang; Ke Wang; Nansheng Chen
Motivation: BLAST users frequently expect to obtain homologous genes with certain similarity to their query genes. But what they get from BLAST searches are often collections of local alignments called high-scoring segment pairs (HSPs). On the other hand, most homology-based gene finders have been built using computation-intensive algorithms, without taking full advantage of BLAST searches that have been perfected over the last decades.
Results: Here we report an efficient algorithm, genBlastG that directly uses the HSPs reported by BLAST to define high-quality gene models.
Availability: http://genome.sfu.ca/genblast/download.html
Contact: chenn@sfu.ca
Supplementary information: Supplementary data are available at Bioinformatics online.
DOI: https://doi.org/10.1093/bioinformatics/btr342
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