proTF
Computational Tool
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General Information
DescriptionA comprehensive data and phylogenomics resource for prokaryotic transcription factors
Homepagehttp://centre.bioinformatics.zj.cn/proTF
Publications
proTF: a comprehensive data and phylogenomics resource for prokaryotic transcription factors
Jie Bai; Junrong Wang; Feng Xue; Jingsong Li; Lijing Bu; Junming Hu; Gang Xu; Qiyu Bao; Guoping Zhao; Xiaoming Ding; Jie Yan; Jinyu Wu
Summary: Investigation of transcription factors (TFs) is of extreme significance for gleaning more information about the mechanisms underlying the dynamic transcriptional regulatory network. Herein, proTF is constructed to serve as a comprehensive data resource and phylogenomics analysis platform for prokaryotic TFs. It has many prominent characteristics: (i) detailed annotation information, including basic sequence features, domain organization, sequence homolog and sequence composition, was extensively collected, and then visually displayed for each TF entry in all prokaryotic genomes; (ii) workset was employed as the basic frame to provide an efficient way to organize the retrieved data and save intermediate records; and (iii) a number of elaborated tools for phylogenomics analysis were implemented to investigate the evolutionary roles of specific TFs. In conclusion, proTF dedicates to the prokaryotic TFs with integrated multi-function, which will become a valuable resource for prokaryotic transcriptional regulatory network in the post-genomic era.
Availability: http://centre.bioinformatics.zj.cn/proTF
Contact: med_bp@zju.edu.cn; iamwujy@yahoo.com.cn
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