TRICIRIBINE (BRD-A42649439)
Overview
- pert_id
- BRD-A42649439
- Name
- triciribine
- Synonyms
- NSC-154020; API-2; S1117; S2732
- Collection
- BIOA
- Summary
- Triciribine (TCN, API-2) is a DNA synthesis inhibitor and also inhibits Akt and HIV-1 with IC50 of 130 nM and 20 nM, respectively.
- MOA
- AKT inhibitor
- Target(s)
- AKT1, AKT2, AKT3
- Indication(s)
- Unknown
- Phase
- Phase 1/Phase 2
- Canonical SMILES
- Cn1nc(N)c2cn(C3OC(CO)C(O)C3O)c4ncnc1c24
- InChI key
- InChIKey=HOGVTUZUJGHKPL-UHFFFAOYSA-N
- InChI string
- InChI=1S/C13H16N6O4/c1-18-11-7-5(10(14)17-18)2-19(12(7)16-4-15-11)13-9(22)8(21)6(3-20)23-13/h2,4,6,8-9,13,20-22H,3H2,1H3,(H2,14,17)
- Molecular formula
- C13H16N6O4
- Molecular weight
- 320.304
External links
- PubChem
- 290486
- Wikipedia
- https://www.caymanchem.com/app/template/Product.vm/catalog/10010237
- SEP-L1000
- BRD-A42649439
Predicted MOAs
| MOA | Probability |
|---|---|
| protein synthesis inhibitor | 0.2153 |
| mTOR inhibitor | 0.1722 |
| CDK inhibitor | 0.0928 |
| Aurora kinase inhibitor | 0.0658 |
| PI3K inhibitor | 0.0439 |
| HSP inhibitor | 0.0431 |
| MEK inhibitor | 0.0389 |
| topoisomerase inhibitor | 0.0298 |
| adrenergic receptor antagonist | 0.0288 |
| RAF inhibitor | 0.0276 |
Chemical structure
