TRICIRIBINE (BRD-K80431395)
Overview
- pert_id
- BRD-K80431395
- Name
- triciribine
- Synonyms
- NSC-154020; API-2; S1117; S2732
- Collection
- BIOA
- Summary
- Triciribine (TCN, API-2) is a DNA synthesis inhibitor and also inhibits Akt and HIV-1 with IC50 of 130 nM and 20 nM, respectively.
- MOA
- AKT inhibitor
- Target(s)
- AKT1, AKT2, AKT3
- Indication(s)
- Unknown
- Phase
- Phase 1/Phase 2
- Canonical SMILES
- Cn1nc(N)c2cn([C@@H]3O[C@H](CO)[C@@H](O)[C@H]3O)c4ncnc1c24
- InChI key
- InChIKey=HOGVTUZUJGHKPL-HTVVRFAVSA-N
- InChI string
- InChI=1S/C13H16N6O4/c1-18-11-7-5(10(14)17-18)2-19(12(7)16-4-15-11)13-9(22)8(21)6(3-20)23-13/h2,4,6,8-9,13,20-22H,3H2,1H3,(H2,14,17)/t6-,8-,9-,13-/m1/s1
- Molecular formula
- C13H16N6O4
- Molecular weight
- 320.304
External links
- PubChem
- 65399
- Wikipedia
- https://www.caymanchem.com/app/template/Product.vm/catalog/10010237
- SEP-L1000
- BRD-K80431395
Predicted MOAs
| MOA | Probability |
|---|---|
| protein synthesis inhibitor | 0.2325 |
| mTOR inhibitor | 0.1960 |
| CDK inhibitor | 0.0859 |
| Aurora kinase inhibitor | 0.0665 |
| PI3K inhibitor | 0.0443 |
| HSP inhibitor | 0.0432 |
| MEK inhibitor | 0.0406 |
| topoisomerase inhibitor | 0.0287 |
| adrenergic receptor antagonist | 0.0282 |
| RAF inhibitor | 0.0275 |
Chemical structure
