AMIODARONE (BRD-K17561142)
Overview
- pert_id
- BRD-K17561142
- Name
- amiodarone
- Synonyms
- S1979
- Collection
- BIOA
- Summary
- Amiodarone HCl is an antiarrhythmic drug for inhibition of ATP-sensitive potassium channel with IC50 of 19.1 μM.
- MOA
- potassium channel blocker
- Target(s)
- ADRB1, CACNA1H, CACNA2D2, KCNA7, KCNH2
- Indication(s)
- ventricular arrhythmias
- Phase
- Launched
- Canonical SMILES
- CCCCc1oc2ccccc2c1C(=O)c3cc(I)c(OCCN(CC)CC)c(I)c3
- InChI key
- InChIKey=IYIKLHRQXLHMJQ-UHFFFAOYSA-N
- InChI string
- InChI=1S/C25H29I2NO3/c1-4-7-11-22-23(18-10-8-9-12-21(18)31-22)24(29)17-15-19(26)25(20(27)16-17)30-14-13-28(5-2)6-3/h8-10,12,15-16H,4-7,11,13-14H2,1-3H3
- Molecular formula
- C25H29I2NO3
- Molecular weight
- 645.312
External links
- PubChem
- 441325
- Wikipedia
- http://en.wikipedia.org/wiki/Amiodarone
- SEP-L1000
- BRD-K17561142
Predicted MOAs
| MOA | Probability |
|---|---|
| adrenergic receptor antagonist | 0.5860 |
| MEK inhibitor | 0.0800 |
| histamine receptor antagonist | 0.0423 |
| cyclooxygenase inhibitor | 0.0416 |
| calcium channel blocker | 0.0347 |
| PI3K inhibitor | 0.0344 |
| topoisomerase inhibitor | 0.0250 |
| estrogen receptor agonist | 0.0189 |
| dopamine receptor antagonist | 0.0152 |
| mTOR inhibitor | 0.0135 |
Chemical structure
Diagnoses (based on Mount Sinai EHR)
Top diagnoses associated with amiodarone:
Co-prescribed Drugs (based on Mount Sinai EHR)
Top coprescribed drugs of amiodarone:
Age Distribution (based on Mount Sinai EHR)
Probability distribution for the prescription of amiodarone across different ages: