LDN-193189 (BRD-K04853698)
Overview
- pert_id
- BRD-K04853698
- Name
- LDN-193189
- Synonyms
- S2618
- Collection
- BIOA
- Summary
- LDN193189 is a selective inhibitor of ALK2 and ALK3 with IC50 of 5 nM and 30 nM, respectively.
- MOA
- bone morphogenic protein inhibitor
- Target(s)
- ACVR1, BMPR1A
- Indication(s)
- Unknown
- Phase
- Preclinical
- Canonical SMILES
- C1CN(CCN1)c1ccc(cc1)-c1cnc2c(cnn2c1)-c1ccnc2ccccc12
- InChI key
- InChIKey=CDOVNWNANFFLFJ-UHFFFAOYSA-N
- InChI string
- InChI=1S/C25H22N6/c1-2-4-24-22(3-1)21(9-10-27-24)23-16-29-31-17-19(15-28-25(23)31)18-5-7-20(8-6-18)30-13-11-26-12-14-30/h1-10,15-17,26H,11-14H2
- Molecular formula
- C25H22N6
- Molecular weight
- 406.482
External links
- PubChem
- 25195294
- Wikipedia
- http://www.selleckchem.com/products/ldn193189.html
- SEP-L1000
- BRD-K04853698
Predicted MOAs
| MOA | Probability |
|---|---|
| dopamine receptor antagonist | 0.3237 |
| Aurora kinase inhibitor | 0.1036 |
| histamine receptor antagonist | 0.1014 |
| CDK inhibitor | 0.0619 |
| protein synthesis inhibitor | 0.0574 |
| PI3K inhibitor | 0.0444 |
| mTOR inhibitor | 0.0302 |
| adrenergic receptor antagonist | 0.0269 |
| NFkB pathway inhibitor | 0.0264 |
| cyclooxygenase inhibitor | 0.0240 |
Chemical structure
