TW-37 (BRD-K28360340)
Overview
- pert_id
- BRD-K28360340
- Name
- TW-37
- Synonyms
- S1121
- Collection
- BIOA
- Summary
- TW-37 is a novel nonpeptide inhibitor to recombinant Bcl-2, Bcl-xL and Mcl-1 with Ki of 0.29 μM, 1.11 μM and 0.26 μM, respectively.
- MOA
- BCL inhibitor
- Target(s)
- BCL2, BCL2L1, MCL1
- Indication(s)
- Unknown
- Phase
- Preclinical
- Canonical SMILES
- CC(C)c1ccccc1Cc1cc(C(=O)Nc2ccc(cc2)S(=O)(=O)c2ccccc2C(C)(C)C)c(O)c(O)c1O
- InChI key
- InChIKey=PQAPVTKIEGUPRN-UHFFFAOYSA-N
- InChI string
- InChI=1S/C33H35NO6S/c1-20(2)25-11-7-6-10-21(25)18-22-19-26(30(36)31(37)29(22)35)32(38)34-23-14-16-24(17-15-23)41(39,40)28-13-9-8-12-27(28)33(3,4)5/h6-17,19-20,35-37H,18H2,1-5H3,(H,34,38)
- Molecular formula
- C33H35NO6S
- Molecular weight
- 573.699
External links
- PubChem
- 11455910
- Wikipedia
- http://www.selleckchem.com/products/TW-37.html
- SEP-L1000
- BRD-K28360340
Predicted MOAs
| MOA | Probability |
|---|---|
| RAF inhibitor | 0.3022 |
| topoisomerase inhibitor | 0.1982 |
| tubulin polymerization inhibitor | 0.0824 |
| retinoid receptor agonist | 0.0681 |
| protein synthesis inhibitor | 0.0535 |
| EGFR inhibitor | 0.0404 |
| MEK inhibitor | 0.0291 |
| glucocorticoid receptor agonist | 0.0182 |
| dopamine receptor antagonist | 0.0166 |
| cyclooxygenase inhibitor | 0.0165 |
Chemical structure
