Signature Report

Signature ID
CPC006_SNUC5_6H:BRD-U94846492-000-01-1:10
Cell Line
SNUC5
Dose
10.0 μM
Time
6 hours
p-value
< 0.0001
Drug Name
quinine
External Links and Downloads
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Gene lists
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QUININE (BRD-U94846492)

Overview

pert_id
BRD-U94846492
Name
quinine
Collection
BIOA
MOA
hemozoin biocrystallization inhibitor
Target(s)
GP9, KCNB2, KCNN4, SLC29A4
Indication(s)
malaria
Phase
Launched
Canonical SMILES
None
InChI key
None
InChI string
None
Molecular formula
None
Molecular weight
0.0

External links

Wikipedia
http://en.wikipedia.org/wiki/Quinine
SEP-L1000
BRD-U94846492

Predicted MOAs

MOA Probability
adrenergic receptor antagonist 0.2347
histamine receptor antagonist 0.2345
dopamine receptor antagonist 0.0788
cyclooxygenase inhibitor 0.0526
NFkB pathway inhibitor 0.0464
mTOR inhibitor 0.0331
tubulin polymerization inhibitor 0.0281
calcium channel blocker 0.0242
HSP inhibitor 0.0232
PARP inhibitor 0.0209

Chemical structure

Image not available

Diagnoses (based on Mount Sinai EHR)

Top diagnoses associated with quinine:

Co-prescribed Drugs (based on Mount Sinai EHR)

Top coprescribed drugs of quinine:

Age Distribution (based on Mount Sinai EHR)

Probability distribution for the prescription of quinine across different ages:

About

LINCS L1000FWD is actively developed by the Ma’ayan Laboratory for the BD2K-LINCS Data Coordination and Integration Center and the Mount Sinai Center for Bioinformatics at the Icahn School of Medicine at Mount Sinai, New York, NY 10029 USA

L1000FWD's web-based tools and services are free for academic, non-profit use, but for commercial uses please contact MSIP for a license.

Contact
Affiliations
Citation

Wang Z, Lachmann A, Keenan AB, Ma'ayan A (2018) L1000FWD: fireworks visualization of drug-induced transcriptomic signatures. Bioinformatics doi: 10.1093/bioinformatics/bty060

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