OLIGOMYCIN-A (BRD-A81541225)
Overview
- pert_id
- BRD-A81541225
- Name
- oligomycin-a
- Synonyms
- CS-10308285; S1478
- Collection
- BIOA
- Summary
- Oligomycin A is a specific inhibitor of complex V (ATP synthase) of the electron transport chain.
- MOA
- ATP synthase inhibitor, ATPase inhibitor
- Target(s)
- ATP5A1
- Indication(s)
- Unknown
- Phase
- Preclinical
- Canonical SMILES
- CCC1CCC2OC3(CC[C@@H](C)C(C[C@H](C)O)O3)[C@H](C)C(OC(=O)C=C[C@@H](C)[C@H](O)[C@@H](C)C(=O)[C@H](C)[C@@H](O)[C@H](C)C(=O)[C@@](C)(O)[C@H](O)[C@@H](C)CC=CC=C1)[C@H]2C
- InChI key
- InChIKey=MNULEGDCPYONBU-VVXVDZGXSA-N
- InChI string
- InChI=1S/C45H74O11/c1-12-34-17-15-13-14-16-27(4)42(51)44(11,53)43(52)32(9)40(50)31(8)39(49)30(7)38(48)26(3)18-21-37(47)54-41-29(6)35(20-19-34)55-45(33(41)10)23-22-25(2)36(56-45)24-28(5)46/h13-15,17-18,21,25-36,38,40-42,46,48,50-51,53H,12,16,19-20,22-24H2,1-11H3/b14-13+,17-15+,21-18+/t25-,26-,27+,28+,29+,30-,31+,32+,33-,34?,35?,36?,38+,40-,41?,42-,44+,45?/m1/s1
- Molecular formula
- C45H74O11
- Molecular weight
- 791.063
External links
- PubChem
- 6364620
- Wikipedia
- http://www.sigmaaldrich.com/catalog/product/sigma/75351?lang=en®ion=US
- SEP-L1000
- BRD-A81541225
Predicted MOAs
| MOA | Probability |
|---|---|
| NFkB pathway inhibitor | 0.2655 |
| protein synthesis inhibitor | 0.1858 |
| glucocorticoid receptor agonist | 0.0859 |
| topoisomerase inhibitor | 0.0625 |
| CDK inhibitor | 0.0533 |
| mTOR inhibitor | 0.0378 |
| tubulin polymerization inhibitor | 0.0377 |
| retinoid receptor agonist | 0.0366 |
| estrogen receptor agonist | 0.0263 |
| cyclooxygenase inhibitor | 0.0177 |
Chemical structure
