MK-2206 (BRD-K68065987)
Overview
- pert_id
- BRD-K68065987
- Name
- MK-2206
- Synonyms
- S1078
- Collection
- BIOA
- Summary
- MK-2206 2HCl is a highly selective inhibitor of Akt1, Akt2 and Akt3 with IC50 of 8 nM, 12 nM and 65 nM, respectively.
- MOA
- AKT inhibitor
- Target(s)
- AKT1, AKT2, AKT3
- Indication(s)
- Unknown
- Phase
- Phase 2
- Canonical SMILES
- NC1(CCC1)c2ccc(cc2)c3nc4ccn5c(=O)[nH]nc5c4cc3c6ccccc6
- InChI key
- InChIKey=ULDXWLCXEDXJGE-UHFFFAOYSA-N
- InChI string
- InChI=1S/C25H21N5O/c26-25(12-4-13-25)18-9-7-17(8-10-18)22-19(16-5-2-1-3-6-16)15-20-21(27-22)11-14-30-23(20)28-29-24(30)31/h1-3,5-11,14-15H,4,12-13,26H2,(H,29,31)
- Molecular formula
- C25H21N5O
- Molecular weight
- 443.928
External links
- PubChem
- 24964624
- Wikipedia
- http://www.selleckchem.com/products/MK-2206.html
- SEP-L1000
- BRD-K68065987
Predicted MOAs
| MOA | Probability |
|---|---|
| mTOR inhibitor | 0.2166 |
| RAF inhibitor | 0.1411 |
| tubulin polymerization inhibitor | 0.0758 |
| CDK inhibitor | 0.0702 |
| PI3K inhibitor | 0.0654 |
| cyclooxygenase inhibitor | 0.0648 |
| Aurora kinase inhibitor | 0.0384 |
| HSP inhibitor | 0.0281 |
| histamine receptor antagonist | 0.0275 |
| dopamine receptor antagonist | 0.0267 |
Chemical structure
