HOMOHARRINGTONINE (BRD-A24643465)
Overview
- pert_id
- BRD-A24643465
- Name
- homoharringtonine
- Collection
- BIOA
- MOA
- protein synthesis inhibitor
- Target(s)
- RPL3
- Indication(s)
- chronic myeloid leukemia (CML)
- Phase
- Launched
- Canonical SMILES
- COC1=C[C@@]23CCCN3CCc4cc5OCOc5cc4[C@]2(C)C1OC(=O)[C@@](O)(CCCC(C)(C)O)CC(=O)O
- InChI key
- InChIKey=DJIVDDPFKDEQIR-XSEHADPMSA-N
- InChI string
- InChI=1S/C29H39NO9/c1-26(2,34)8-5-9-28(35,16-23(31)32)25(33)39-24-22(36-4)15-29-10-6-11-30(29)12-7-18-13-20-21(38-17-37-20)14-19(18)27(24,29)3/h13-15,24,34-35H,5-12,16-17H2,1-4H3,(H,31,32)/t24?,27-,28-,29+/m1/s1
- Molecular formula
- C29H39NO9
- Molecular weight
- 545.621
External links
- PubChem
- 16219462
- Wikipedia
- http://www.sigmaaldrich.com/catalog/product/sigma/h0635?lang=en®ion=US
- SEP-L1000
- BRD-A24643465
Predicted MOAs
| MOA | Probability |
|---|---|
| protein synthesis inhibitor | 0.9880 |
| topoisomerase inhibitor | 0.0021 |
| tubulin polymerization inhibitor | 0.0011 |
| mTOR inhibitor | 0.0010 |
| adrenergic receptor antagonist | 0.0008 |
| histamine receptor antagonist | 0.0006 |
| glucocorticoid receptor agonist | 0.0006 |
| dopamine receptor antagonist | 0.0005 |
| CDK inhibitor | 0.0005 |
| HSP inhibitor | 0.0005 |
Chemical structure
