TOPOTECAN (BRD-A59985574)
Overview
- pert_id
- BRD-A59985574
- Name
- topotecan
- Synonyms
- nogitecan; S1231
- Collection
- BIOA
- Summary
- Topotecan (Hycamtin, NSC 609699) is a topoisomerase I inhibitor for MCF-7 Luc cells and DU-145 Luc cells with IC50 of 13 nM and 2 nM, respectively.
- MOA
- topoisomerase inhibitor
- Target(s)
- TOP1, TOP1MT
- Indication(s)
- small cell lung cancer, cervical cancer
- Phase
- Launched
- Canonical SMILES
- CCC1(O)C(=O)OCc2c1cc1-c3nc4ccc(O)c(CN(C)C)c4cc3Cn1c2=O
- InChI key
- InChIKey=UCFGDBYHRUNTLO-UHFFFAOYSA-N
- InChI string
- InChI=1S/C23H23N3O5/c1-4-23(30)16-8-18-20-12(9-26(18)21(28)15(16)11-31-22(23)29)7-13-14(10-25(2)3)19(27)6-5-17(13)24-20/h5-8,27,30H,4,9-11H2,1-3H3
- Molecular formula
- C23H23N3O5
- Molecular weight
- 457.907
External links
- PubChem
- 5515
- Wikipedia
- http://en.wikipedia.org/wiki/Topotecan
- SEP-L1000
- BRD-A59985574
Predicted MOAs
| MOA | Probability |
|---|---|
| topoisomerase inhibitor | 0.9599 |
| protein synthesis inhibitor | 0.0102 |
| adrenergic receptor antagonist | 0.0028 |
| PARP inhibitor | 0.0022 |
| tubulin polymerization inhibitor | 0.0022 |
| PI3K inhibitor | 0.0021 |
| mTOR inhibitor | 0.0020 |
| CDK inhibitor | 0.0019 |
| RAF inhibitor | 0.0017 |
| MEK inhibitor | 0.0014 |
Chemical structure
Diagnoses (based on Mount Sinai EHR)
Top diagnoses associated with topotecan:
Co-prescribed Drugs (based on Mount Sinai EHR)
Top coprescribed drugs of topotecan:
Age Distribution (based on Mount Sinai EHR)
Probability distribution for the prescription of topotecan across different ages: